#066-070: Caffeine for apnea of prematurity

Hello friends 👋

Have you ever wondered: who had the idea to give caffeine to babies? We certainly did. Caffeine is an ubiquitous medication in the NICU, and yet I can hardly remember anyone teaching me about how the practice of treating apnea of prematurity using caffeine came about.

This week Daphna and I do a deep dive into the history of caffeine and the pathophysiology of apnea of prematurity.

The articles discussed on the show this week are linked below.

We are also attaching the notes Daphna and I took on the CAP trial and

We are also sharing a presentation covering the points discussed on this week's podcast episodes. This presentation aims to make clinical teaching more convenient if you wanted to teach the material covered on the podcast this week. Enjoy!

Apnoeic attacks in the newborn treated with aminophylline.

Archives of Disease in ChildhoodInstructions for authors

https://www.jpeds.com/article/S0022-3476(77)80718-X/pdf

Caffeine Therapy for Apnea of Prematurity | NEJM

Original Article from The New England Journal of Medicine — Caffeine Therapy for Apnea of Prematurity

New England Journal of MedicineRenew

Long-Term Effects of Caffeine Therapy for Apnea of Prematurity | NEJM

Original Article from The New England Journal of Medicine — Long-Term Effects of Caffeine Therapy for Apnea of Prematurity

New England Journal of MedicineRenew

Survival Without Disability to Age 5 Years After Neonatal Caffeine Therapy for Apnea of Prematurity

Context Very preterm infants are prone to apnea and have an increased risk of death or disability. Caffeine therapy for apnea of prematurity reduces the rates of cerebral palsy and cognitive delay at 18 months of age.Objective To determine whether neonatal caffeine therapy has lasting benefits or...

JAMA NetworkFor Authors

Performance 11 Years After Caffeine Therapy for Apnea of Prematurity

This follow-up study to the Caffeine for Apnea of Prematurity trial evaluates whether neonatal caffeine citrate therapy is associated with improved functional outcomes 11 years later.

JAMA NetworkFor Authors

Pathophysiologic Mechanisms Underlying Apnea of Prematurity

After completing this article, readers should be able to: Idiopathic apnea of prematurity is a common disorder that requires therapeutic intervention to avoid potential morbidity in preterm infants who require neonatal intensive care. Severe, recurrent apneic episodes may lead to multiple investigat…

American Academy of PediatricsRichard J. Martin

https://publications.aap.org/neoreviews/article-abstract/3/4/e59/86973/Pathophysiologic-Mechanisms-Underlying-Apnea-of?redirectedFrom=fulltext

Notes on the CAP Trial:

Presentation (check presentation notes for more content per slide):